San Diego is about 1.5 times smaller than Rome.

Rome is approximately 1,287 sq km, while San Diego is approximately 844 sq km, making San Diego 65.56% the size of Rome.
Tip: This to-scale comparison of Rome vs. San Diego uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.