Pittsburgh is about 1.2 times bigger than San Francisco.

San Francisco (including the city proper only) is approximately 121 sq km, while Pittsburgh is approximately 143 sq km, making Pittsburgh 19% larger than San Francisco.
Tip: This to-scale comparison of San Francisco vs. Pittsburgh uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.