New York City is about 100 times smaller than South Carolina.

South Carolina is approximately 77,983 sq km, while New York City (including all five boroughs: Manhattan, Brooklyn, Queens, The Bronx, and Staten Island) is approximately 781 sq km, making New York City 1.0% the size of South Carolina.
Tip: This to-scale comparison of South Carolina vs. New York City uses the Mercator projection, which distorts the size of regions near the poles.