New York City is about 2.7 times bigger than Fort Wayne.

Fort Wayne (map shows its 315 named neighbourhoods; the area covers the whole city) is approximately 289 sq km, while New York City (including all five boroughs: Manhattan, Brooklyn, Queens, The Bronx, and Staten Island) is approximately 781 sq km, making New York City 170% larger than Fort Wayne.
Tip: This to-scale comparison of Fort Wayne vs. New York City uses the Mercator projection, which distorts the size of regions near the poles.
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