Moscow is about 21 times bigger than San Francisco.

San Francisco (including the city proper only) is approximately 121 sq km, while Moscow (map shows its 125 districts within the pre-2012 boundary; the area includes New Moscow) is approximately 2,562 sq km, making Moscow 2,017% larger than San Francisco.
Tip: This to-scale comparison of San Francisco vs. Moscow uses the Mercator projection, which distorts the size of regions near the poles.
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