Melbourne is about 32 times bigger than San Francisco.

San Francisco (including the city proper only) is approximately 121 sq km, while Melbourne (the 27 councils of metropolitan Melbourne, without the Yarra Ranges, Cardinia, Mornington Peninsula and Nillumbik) is approximately 3,915 sq km, making Melbourne 3,136% larger than San Francisco.
Tip: This to-scale comparison of San Francisco vs. Melbourne uses the Mercator projection, which distorts the size of regions near the poles.
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