Madrid is about 2.1 times smaller than San Antonio.

San Antonio (map shows its 401 named neighbourhoods; the area covers the whole city) is approximately 1,292 sq km, while Madrid is approximately 604 sq km, making Madrid 46.76% the size of San Antonio.
Tip: This to-scale comparison of San Antonio vs. Madrid uses the Mercator projection, which distorts the size of regions near the poles.
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