Little Rock is about 2.6 times bigger than San Francisco.

San Francisco (including the city proper only) is approximately 121 sq km, while Little Rock (map shows its 28 named neighbourhoods; the area covers the whole city) is approximately 314 sq km, making Little Rock 160% larger than San Francisco.
Tip: This to-scale comparison of San Francisco vs. Little Rock uses the Mercator projection, which distorts the size of regions near the poles.
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