Colorado Springs is about 4.3 times bigger than San Francisco.

San Francisco (including the city proper only) is approximately 121 sq km, while Colorado Springs (map shows its 11 named neighbourhoods; the area covers the whole city) is approximately 523 sq km, making Colorado Springs 333% larger than San Francisco.
Tip: This to-scale comparison of San Francisco vs. Colorado Springs uses the Mercator projection, which distorts the size of regions near the poles.
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