Buffalo is about 16 times smaller than Houston.

Houston is approximately 1,659 sq km, while Buffalo is approximately 105 sq km, making Buffalo 6.3% the size of Houston.
Tip: This to-scale comparison of Houston vs. Buffalo uses the Mercator projection, which distorts the size of regions near the poles.
Our free app, MapSize by MyLifeElsewhere — compare any two places, to scale on your mobile device.