Ghana is about 247 times bigger than Sao Tome and Principe.

Sao Tome and Principe is approximately 964 sq km, while Ghana is approximately 238,533 sq km, making Ghana 24,644% larger than Sao Tome and Principe. Meanwhile, the population of Sao Tome and Principe is ~217,164 people (32.9 million more people live in Ghana).
This to-scale comparison of Sao Tome and Principe vs. Ghana uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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