Dominican Republic is about 1.6 times smaller than Panama.

Panama is approximately 75,420 sq km, while Dominican Republic is approximately 48,670 sq km, making Dominican Republic 64.53% the size of Panama. Meanwhile, the population of Panama is ~4.3 million people (6.4 million more people live in Dominican Republic).
This to-scale comparison of Panama vs. Dominican Republic uses the Mercator projection, which distorts the size of regions near the poles. Learn more.

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